Biomimetic hierarchical nanofibrous surfaces inspired by superhydrophobic lotus leaf structure for preventing tissue adhesions

Undesirable tissue adhesions remain one of the most common and dreaded postoperative complications. Biocompatible nanofibrous mats with antiadhesive surfaces represent a promising barrier method for preventing formation adhesions. The material developed in this work was inspired by natural superhydrophobic lotus leaf nanostructure, which mimicked unique combination needleless electrospraying electrospinning technology poly-?-caprolactone (PCL). surface hydrophobicity electrosprayed nanodroplets further enhanced cold plasma modification using chemical vapor deposition (CVD) hexamethyldisiloxane (HMDSO). treatment led to successful decrease wettability our samples. Morphology (scanning electron microscopy), (contact angle) composition (FTIR analysis) were observed period six months track possible changes; obtained results verified presence HMDSO during whole time period. Cytocompatibility confirmed vitro 3T3 mouse fibroblasts according norm ISO 10993-5. Cell adhesion proliferation assessed metabolic MTT assay fluorescence microscopy after 4, 7, 14 days. Antiadhesive behaviour atomic force ex vivo peel test 90° intestinal tissue, final structure has great potential reduce